Cross-linking of Collagen and Fibronectin
نویسندگان
چکیده
Fibronectin is a large glycoprotein which is found in body fluids and media of cultured cells. Insoluble fibronectin is found in tissue stroma and in collagen-containing extracellular matrices of cultured cells. Fibronectin is a substrate for Factor XIIIa (plasma transglutaminase) and can be cross-linked by this enzyme to types I and 111 collagen (Mosher, D. F., Schad, P. E., and Kleinman, H. K. (1979) J. Clin. Invest., 64, 781-787). Cross-linking to collagen is inhibited by dansylcadaverine, spermine, spermidine, and putrescine (Mosher, D. F., Schad, P. E., and Kleinman, H. K. (1979) J. Supm-
منابع مشابه
Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa.
Soluble fibronectin is found in body fluids and media of adherent cultured cells and binds to fibrin and collagen. Insoluble fibronectin is found in tissue stroma and in extracellular matrices of cultured cells. Fibronectin is a substrate for Factor XIIIa (plasma transglutaminase) and can be cross-linked by Factor XIIIa to itself and the the alpha-chain of fibrin. We used sodium dodecyl sulfate...
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